Endothelial cell-derived extracellular vesicles impair the angiogenic response of coronary artery endothelial cells.

ABSTRACT: Cardiovascular disease (CVD) is the most prominent cause of death of adults in the United States with coronary artery disease being the most common type of CVD. Following a myocardial event, the coronary endothelium plays an important role in the recovery of the ischemic myocardium. Specifically, endothelial cells (EC) must be able to elicit a robust angiogenic response necessary for tissue revascularization and repair. However, local or distant cues may prevent effective revascularization. Extracellular vesicles (EV) are produced by all cells and endothelium is a rich source of EVs that have access to the main circulation thereby potentially impacting local and distant tissue function. Systemic inflammation associated with conditions such as obesity as well as the acute inflammatory respo

SUBMITTER: Carter N 

PROVIDER: S-EPMC9343725 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature