Antibody dynamics in children with first or repeat Plasmodium falciparum infections.

ABSTRACT: Immunoglobulin (Ig) production during and after infection with Plasmodium parasites is one of the greatest adaptive immune defenses the human host has against this parasite. Infection with P. falciparum has been shown to induce different B cell maturation responses dependent upon the age of the patient, number of previous exposures, and severity of the disease. Described here are dynamics of Ig responses to a panel of 32 P. falciparum antigens by patients followed for 42 days and classified individuals as showing characteristics of an apparent first P. falciparum infection (naïve) or a repeat exposure (non-naïve). Six parameters were modeled to characterize the dynamics of IgM, IgG₁, IgG₃, and IgA for these two exposure groups with differen

SUBMITTER: Rogier E 

PROVIDER: S-EPMC9343764 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature