Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model.

ABSTRACT: Tissue-engineered skin constructs have been under development since the 1980s as a replacement for human skin tissues and animal models for therapeutics and cosmetic testing. These have evolved from simple single-cell assays to increasingly complex models with integrated dermal equivalents and multiple cell types including a dermis, epidermis, and vasculature. The development of micro-engineered platforms and biomaterials has enabled scientists to better recreate and capture the tissue microenvironment in vitro, including the vascularization of tissue models and their integration into microfluidic chips. However, to date, microvascularized human skin equivalents in a microfluidic context have not been reported. Here, we present the design of a novel skin-on-a-chip model integrating

SUBMITTER: Jones CFE 

PROVIDER: S-EPMC9343775 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature