Association Between Polymorphisms in Estrogen Receptor Genes and Depression in Women: A Meta-Analysis.

ABSTRACT: Objective: It is suggested that estrogen receptors (ERs) might be associated with the disproportionate vulnerability of women to depressive episodes. Several variants in ER-alpha (ERα) and ER-beta (ERβ) have been linked to depression, but the results were not consistent. Hence, we conducted a meta-analysis to evaluate the association between ERα/ERβ and depression in a cohort of women. Methods: A comprehensive literature search was performed in public databases. The genetic association between polymorphisms in Erα/ERβ and depression risk in a cohort of women was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). Cochran's Q test and the I² index were used to evaluate heterogeneity. Results: In total, 10 studies and 4 SNPs (rs2234693, rs934079

SUBMITTER: Li C 

PROVIDER: S-EPMC9343944 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature