Force-Bioreactor for Assessing Pharmacological Therapies for Mechanobiological Targets

ABSTRACT: Tissue fibrosis is a major health issue that impacts millions of people and is costly to treat. However, few effective anti-fibrotic treatments are available. Due to their central role in fibrotic tissue deposition, fibroblasts and myofibroblasts are the target of many therapeutic strategies centered primarily on either inducing apoptosis or blocking mechanical or biochemical stimulation that leads to excessive collagen production. Part of the development of these drugs for clinical use involves in vitro prescreening. 2D screens, however, are not ideal for discovering mechanobiologically significant compounds that impact functions like force generation and other cell activities related to tissue remodeling that are highly dependent on the conditions of the microenvironment. Thus, higher fi

SUBMITTER: Scholp A 

PROVIDER: S-EPMC9343955 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature