Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma.

ABSTRACT:

Purpose

To test the hypothesis that newly developed shape measures using optical coherence tomography (OCT) macular volume scans can discriminate patients with perimetric glaucoma from healthy subjects.

Methods

OCT structural measures defining macular topography and volume were recently developed based on cubic Bézier curves. We exported macular volume scans from 135 eyes with glaucoma (133 patients) and 155 healthy eyes (85 subjects) and estimated global and quadrant-based measures. The best subset of measures to predict glaucoma was explored with a gradient boost model (GBM) with subsequent logistic regression. Accuracy and area under receiver operating curves (AUC) were the primary metrics. In addition, we separately investigated model performance in 66 eyes with mild gla

SUBMITTER: Mohammadzadeh V 

PROVIDER: S-EPMC9344219 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature