The STAT3 inhibitor GPB730 enhances the sensitivity to enzalutamide in prostate cancer cells.

ABSTRACT: Enzalutamide is a second-generation anti-androgen which has shown increased survival in patients with metastatic prostate cancer. However, some patients do not respond to this therapy or will develop resistance to treatment over time. Signal Transducer and Activator of Transcription 3 (STAT3) is known to be involved in castration-resistant prostate cancer and to interact with androgen receptor (AR)-signaling. This study aims to investigate the combination enzalutamide and the small molecule STAT3 inhibitor GPB730 for enhanced therapeutic effect in advanced prostate cancer in vitro. The prostate cancer cell lines LNCaP (androgen dependent) and C4-2 (androgen insensitive) were used. The effect of enzalutamide and GPB730, alone and in combination, was investigated on viability and IC_50</

SUBMITTER: Hellsten R 

PROVIDER: S-EPMC9344336 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature