Metabolic reprogramming by adenosine antagonism and implications in non-small cell lung cancer therapy.

ABSTRACT: Non-small cell lung cancer (NSCLC) is a heterogeneous disease with genetic and environmental parameters that influence cell metabolism. Because of the complex interplay of environmental factors within the tumor microenvironment (TME) and the profound impact of these factors on the metabolic activities of tumor and immune cells, there is an emerging interest to advance the understanding of these diverse metabolic phenotypes in the TME. High levels of adenosine are characteristic of the TME, and adenosine can have a significant impact on both tumor cell growth and the immune response. Consistent with this, we showed in NSCLC data from TCGA that high expression of the A2BR leads to worse outcome and that expression of A2BR may be different for different mutation backgrounds. We then investiga

SUBMITTER: Guan S 

PROVIDER: S-EPMC9344351 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature