Real-world Associations of US Cystic Fibrosis Newborn Screening Programs With Nutritional and Pulmonary Outcomes.

ABSTRACT:

Importance

Newborn screening (NBS) for cystic fibrosis (CF) has been universal in the US since 2010, but its association with clinical outcomes is unclear.

Objective

To describe the real-world effectiveness of NBS programs for CF in the US on outcomes up to age 10 years.

Design, setting, and participants

This was a retrospective cohort study using CF Foundation Patient Registry data from January 1, 2000, to December 31, 2018. The staggered implementation of NBS programs by state was used to compare longitudinal outcomes among children in the same birth cohort born before vs after the implementation of NBS for CF in their state of birth. Participants included children with an established diagnosis of CF born between January 1, 2000, to December 31, 2018, in any of the

SUBMITTER: Rosenfeld M 

PROVIDER: S-EPMC9344390 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature