A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas.
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ABSTRACT:
SUBMITTER: Skorupan N
PROVIDER: S-EPMC9344435 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas.
Skorupan Nebojsa N Ahmad Mehwish I MI Steinberg Seth M SM Trepel Jane B JB Cridebring Derek D Han Haiyong H Von Hoff Daniel D DD Alewine Christine C
Future oncology (London, England) 20220510 20
Adenosquamous carcinoma of the pancreas (ASCP) is a very rare and highly aggressive variant of pancreatic ductal adenocarcinoma, accounting for 0.5-4% of all pancreatic cancer cases in the USA. Current data indicate that epigenetic changes and <i>MYC</i> overexpression lead to squamous transdifferentiation of pancreatic tumor cells and development of ASCP. Minnelide™, an oral anti-super-enhancer drug that inhibits <i>MYC</i> expression in preclinical models of ASCP, has demonstrated safety in a ...[more]
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