Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma.

ABSTRACT: Objective: Compare health-related quality of life (HRQoL) of selinexor versus placebo in patients with dedifferentiated liposarcoma. Materials & methods: HRQoL was assessed at baseline and day 1 of each cycle using the European Organization for Research and Treatment of Cancer 30-item core quality of life questionnaire. Results were reported from baseline to day 169 (where exposure to treatment was maximized while maintaining adequate sample size). Results: Pain scores worsened for placebo versus selinexor across all postbaseline visits, although differences in HRQoL at some visits were not significant. Other domains did not exhibit significant differences between arms; however, scores in both arms deteriorated over time. Conclusion: Patients treated with seline

SUBMITTER: Gounder M 

PROVIDER: S-EPMC9344436 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature