Tick-borne encephalitis affects sleep-wake behavior and locomotion in infant rats.

ABSTRACT:

Background/aims

Tick-borne encephalitis (TBE) is a disease affecting the central nervous system. Over the last decade, the incidence of TBE has steadily increased in Europe and Asia despite the availably of effective vaccines. Up to 50% of patients after TBE suffer from post-encephalitic syndrome that may develop into long-lasting morbidity. Altered sleep-wake functions have been reported by patients after TBE. The mechanisms causing these disorders in TBE are largely unknown to date. As a first step toward a better understanding of the pathology of TBEV-inducing sleep dysfunctions, we assessed parameters of sleep structure in an established infant rat model of TBE.

Methods

13-day old Wistar rats were infected with 1 × 10⁶ FFU Langat virus (LGTV). On day 4, 9, and

SUBMITTER: Chiffi G 

PROVIDER: S-EPMC9344439 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature