Immunophenotypic changes of monocytes in myelodysplastic syndrome and clinical significance.

ABSTRACT:

Background

Myelodysplastic syndrome (MDS) is a type of heterogeneous myeloid clonal disorder usually diagnosed based on a combination of multiple laboratory examinations, including analysis of peripheral blood cells, bone marrow cell morphology and cytogenetics. However, there is a certain difficulty in cases with no distinct changes in hematology and marrow cell morphology.

Methods

We adopt flow cytometry to quantitatively analyze the immunophenotypic changes of marrow monocytes according to the surface antigens and their combinations at different differentiation stages, so as to study the changes of monocytes during differentiation in patients with bone marrow failure. In the meantime, the relationship between the immunophenotypic changes of marrow monocytes and IPSS-R sco

SUBMITTER: Li L 

PROVIDER: S-EPMC9344451 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature