Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.

ABSTRACT: Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels' function can lead to many pathophysiological conditions. Nav channels are composed of several functional and structural domains that could be targeted pharmacologically as potential therapeutic means against various neurological conditions. Mutations in Nav channels have been suggested to underlie various clinical syndromes in different tissues and in association with conditions ranging from epileptic to muscular problems. Treating those mutations that increase the excitability of Nav channels requires inhibitors that could effectively reduce channel firing. The main non-psychotropic constituent of the cannabis plant, cannabidiol (CBD), has recently gained interest as a viable comp

SUBMITTER: Ghovanloo MR 

PROVIDER: S-EPMC9344566 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature