Cumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis

ABSTRACT: Abstract

Background and Aim

Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In this study, we aimed to reevaluate the transition of new symptom development in PBC and its predictive factors.

Methods

This retrospective multicenter study enrolled 382 patients with PBC for symptom analysis. The impact of a newly developed symptom on PBC prognosis was investigated by Kaplan–Meier analysis with propensity score matching and logistic progression analysis.

Results

The cumulative risk of developing a new symptom after 10 and 20 years of follow‐up was 7.6 and 28.2%, and specifically that of pruritus, which

SUBMITTER: Kimura N 

PROVIDER: S-EPMC9344586 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature