Sleep duration, genetic susceptibility, and Alzheimer's disease: a longitudinal UK Biobank-based study.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most frequently occurring type of dementia. Concurrently, inadequate sleep has been recognized as a public health epidemic. Notably, genetic and environmental factors are now considered contributors to AD progression.

Objective

To assess the association between sleep duration, genetic susceptibility, and AD.

Methods and results

Based on 483,507 participants from the UK Biobank (UKB) with an average follow-up of 11.3 years, there was a non-linear relationship between AD incidence and sleep duration (P for non-linear < 0.001) by restricted cubic splines (RCS). Sleep duration was categorized into short sleep duration (< 6 h/night), normal sleep duration (6-9 h/night), and long sleep duration (> 9 h/night). No statistically signi

SUBMITTER: Yuan S 

PROVIDER: S-EPMC9344659 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature