SPEAR: Systematic ProtEin AnnotatoR.
Ontology highlight
ABSTRACT: Summary
We present Systematic ProtEin AnnotatoR (SPEAR), a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real time and features a powerful interactive data visualization report.Availability and implementation
SPEAR and documentation are freely available on GitHub: https://github.com/m-crown/SPEAR and are implemented in Python and installable via Conda environment.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Crown M
PROVIDER: S-EPMC9344845 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
SPEAR: Systematic ProtEin AnnotatoR.
Crown Matthew M Teruel Natália N Najmanovich Rafael R Bashton Matthew M
Bioinformatics (Oxford, England) 20220801 15
<h4>Summary</h4>We present Systematic ProtEin AnnotatoR (SPEAR), a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real time and features a powerful interactive data visualization report.<h4>Availability and implementation</h4>SPEAR and documentation are freely available on Gi ...[more]
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