Short-time intensive insulin therapy upregulates 3 beta- and 17 beta-hydroxysteroid dehydrogenase levels in men with newly diagnosed T2DM.

ABSTRACT:

Objective

Our previous study has found that short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes mellitus (T2DM) increased serum testosterone levels, but the underlying mechanisms remain unclear.

Design and methods

In this self-controlled study, 43 men with newly diagnosed drug naïve T2DM, aged 18-60 years, with HbA_{1c >}9.0% were treated with continuous subcutaneous insulin infusion (CSII) to normalize blood glucose within one week. Venous blood specimens were collected for measuring of serum total testosterone, dehydroepiandrosterone sulfate (DHEA-S), 3β- and 17β-hydroxysteroid dehydrogenase (3β- and 17β-HSD) concentrations before and after insulin therapy.

Results

Testosterone increased from 13.0 (11.3, 14.6) nmol/L to 15.7

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9344891 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature