Spatial Transcriptomics as a Novel Approach to Redefine Electrical Stimulation Safety.

ABSTRACT: Current standards for safe delivery of electrical stimulation to the central nervous system are based on foundational studies which examined post-mortem tissue for histological signs of damage. This set of observations and the subsequently proposed limits to safe stimulation, termed the "Shannon limits," allow for a simple calculation (using charge per phase and charge density) to determine the intensity of electrical stimulation that can be delivered safely to brain tissue. In the three decades since the Shannon limits were reported, advances in molecular biology have allowed for more nuanced and detailed approaches to be used to expand current understanding of the physiological effects of stimulation. Here, we demonstrate the use of spatial transcriptomics (ST) in an exploratory investig

SUBMITTER: Whitsitt QA 

PROVIDER: S-EPMC9344921 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature