The Interplay Between Use of Biological Therapies, Psychological State, and the Microbiome in IBD.

ABSTRACT:

Background

This study examines longitudinal bio-psychological dynamics and their interplay in IBD patients undergoing conventional and biological therapies.

Methods

Fifty IBD participants (24 UC, 26 CD) in clinical remission were followed for 12 months. Complete longitudinal datasets, biological samples, validated scores of psychological status were collected monthly for analysis of association. Microbiome analysis was performed to identify microbial dynamics and signatures. Patients were grouped on disease phenotype (CD, UC) and mode of treatment (biological therapies, non-biological treatment). General linear models, mixed models, cluster analysis, and analyses of variance were used to examine the longitudinal trends of the variables and their associations over time. Resul

SUBMITTER: Tavakoli P 

PROVIDER: S-EPMC9345200 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature