Biodegradable microneedle patch for delivery of meloxicam for managing pain in cattle.

ABSTRACT: Microneedle patches are a promising source for transdermal diffusion of macromolecules and are designed to painlessly penetrate the skin. In this study, a biodegradable chitosan microneedle patch to deliver meloxicam for managing pain in cattle was tested. The potential of reuse of the polymeric solution to fabricate the patches, optimization of fabrication, morphological analysis of the microneedle patch and analysis of preservation of the chemical composition after sterilization were evaluated. In-vitro analysis consisted of studying in-vitro penetration mechanical properties, compression testing analysis of microneedle patch, and in-vitro drug release analysis. In-vivo studies were performed to analyze the dissolution capability of the microneedle patch. Results regarding the physical c

SUBMITTER: Castilla-Casadiego DA 

PROVIDER: S-EPMC9345335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature