Evaluation of sperm integrin α5β1 as a potential marker of fertility in humans.

ABSTRACT: Sperm selection for assisted reproduction techniques is generally based on basic parameters, while key aspects of sperm competence and its journey from the deposition site to the fertilization site are overlooked. Consequently, identifying molecular markers in spermatozoa that can efficiently predict the fertility of a semen sample could be of great interest, particularly in cases of idiopathic male infertility. When spermatozoa reach the female reproductive tract, it provides to them the cellular and molecular microenvironment needed to acquire fertilizing ability. In this sense, considering the role that integrin α5β1 of spermatozoa plays in reproduction-related events, we investigated the correlation between the subcellular localization of sperm integrin α5β1 and early embryo developmen

SUBMITTER: Vernaz ZJ 

PROVIDER: S-EPMC9345343 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature