A three component model for superdiffusive motion effectively describes migration of eukaryotic cells moving freely or under a directional stimulus.

ABSTRACT: Although the simple diffusion model can effectively describe the movement of eukaryotic cells on a culture surface observed at relatively low sampling frequency, at higher sampling rates more complex models are often necessary to better fit the experimental data. Currently available models can describe motion paths by involving additional parameters, such as linearity or directional persistence in time. However sometimes difficulties arise as it is not easy to effectively evaluate persistence in presence of a directional bias. Here we present a procedure which helps solve this problem, based on a model which describes displacement as the vectorial sum of three components: diffusion, persistence and directional bias. The described model has been tested by analysing the migratory behaviour o

SUBMITTER: Toscano E 

PROVIDER: S-EPMC9345344 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature