Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience?

ABSTRACT: Abstract

Introduction

SuperAgers are individuals over age 80 with superior episodic memory, at a level consistent with individuals 20 to 30 years their junior and who seem to show resistance to age‐related neurofibrillary degeneration. Here we examine whether low genetic risk for Alzheimer's disease (AD) contributes to SuperAgers’ unusually high episodic memory performance in advanced age.

Methods

The AD polygenic hazard score (PHS) was calculated for each SuperAger and cognitively normal participant and compared between groups.

Results

A total of 37 SuperAgers (73% female, mean [standard deviation] 82.7 [2.8] years old) and 35 controls (54% female, 83.7 [4.3] years old) were included. There was no significant difference in the AD PHS between SuperAgers and cogni

SUBMITTER: Spencer B 

PROVIDER: S-EPMC9345399 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature