STAT3 gain-of-function is not responsible for low total IgE levels in patients with autoimmune chronic spontaneous urticaria.

ABSTRACT:

Background

The pathogenesis of chronic spontaneous urticaria (CSU) has not been clarified entirely. Type IIb autoimmune chronic spontaneous urticaria (CSU^aiTIIb) is a distinct subtype of CSU that is often difficult to treat and is connected to low levels of total IgE. Previous findings indicate that an enhanced signal transducer and activator of transcription 3 (STAT3) may be responsible for reduced IgE serum levels.

Objective

Our aim was to investigate a possible underlying gain-of-function mutation or activating polymorphism in STAT3 that could be responsible for the low levels of IgE in patients with CSU^aiTIIb.

Methods

We included 10 patients with CSU^aiTIIb and low levels of IgE and sequenced selected single nucleotide polymo

SUBMITTER: Sauer M 

PROVIDER: S-EPMC9345496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature