Polymyxin B Hemoperfusion in Pediatric Septic Shock: Single-Center Observational Case Series.

ABSTRACT:

Objectives

To evaluate the use of direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) as adjunctive therapy during pediatric patients with septic shock.

Design

Prospective observational study.

Setting

Nine-bed PICUs at university referral hospital.

Patients

Children (30 d to 15 yr) with septic shock and Pediatric Logistic Organ Dysfunction (PELOD)-2 score greater than or equal to 10 or Pediatric Risk of Mortality (PRISM) 3 score greater than or equal to 15, who were also receiving at least one inotrope.

Intervention

Patients received 2-4 hour treatment with PMX-DHP 20R column on 2 consecutive days.

Measurements and main results

We enrolled six children aged 21-167 months old (median, 99-mo old), with a body weight of 10-50 kg (median

SUBMITTER: Saetang P 

PROVIDER: S-EPMC9345520 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature