GNG12 as A Novel Molecular Marker for the Diagnosis and Treatment of Glioma.

ABSTRACT:

Purpose

GNG12 influences a variety of tumors; however, its relationship with glioma remains unclear. The aim of this study was to comprehensively investigate the relationship between GNG12 and the clinical characteristics and prognosis of glioma patients and reveal the mechanisms causing the malignant process of GNG12.

Materials and methods

We obtained information on clinical samples from multiple databases. The expression level of GNG12 was validated using a RT-qPCR and IHC. KM curves were used to assess the correlation between the GNG12 expression and OS of glioma patients. An ROC curve was drawn to assess the predictive performance of GNG12. Univariate and multivariate Cox analyses were performed to analyze the factors affecting the prognosis of patients with glioma. GSEA

SUBMITTER: Liu R 

PROVIDER: S-EPMC9345608 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature