Effectiveness of mRNA booster vaccine among health Care workers in New York City during the omicron surge, December 2021- January 2022

ABSTRACT:

Objectives

To describe effectiveness of mRNA vaccines by comparing 2-dose (2D) and 3-dose (3D) healthcare worker (HCW) recipients in the setting of Omicron variant dominance. Performance of 2D and 3D vaccine series against SARS-CoV-2 variants and the clinical outcomes of HCWs may inform return-to-work guidance.

Methods

In a retrospective study from December 15, 2020 – January 15, 2022, SARS CoV-2 infections among HCWs at a large tertiary cancer center in New York City (NYC) were examined to estimate infection rates over the omicron period (aggregated positive tests/person-days) and 95% CIs in 2D and 3D mRNA vaccinated HCWs and were compared using rate ratios. We describe the clinical features of post-vaccine infections and impact of prior (pre-Omicron) COVID infection on

SUBMITTER: Robilotti E 

PROVIDER: S-EPMC9345790 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature