Pattern of arterial inflammation and inflammatory markers in people living with HIV compared with uninfected people.

ABSTRACT:

Study design

To compare arterial inflammation (AI) between people living with HIV (PLWH) and uninfected people as assessed by ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG)-positron emission tomography (PET).

Methods

We prospectively enrolled 20 PLWH and 20 uninfected people with no known cardiovascular disease and at least 3 traditional cardiovascular risk factors. All patients underwent ¹⁸F-FDG-PET/computed tomography (CT) of the thorax and neck. Biomarkers linked to inflammation and atherosclerosis were also determined. The primary outcome was AI in ascending aorta (AA) measured as mean maximum target-to-background ratio (TBR_max). The independent relationships between HIV status and both TBR_max and biomarkers were evaluated by mult

SUBMITTER: Taglieri N 

PROVIDER: S-EPMC9345795 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature