Birthweight, BMI in adulthood and latent autoimmune diabetes in adults: a Mendelian randomisation study.

ABSTRACT:

Aims/hypothesis

Observational studies have found an increased risk of latent autoimmune diabetes in adults (LADA) associated with low birthweight and adult overweight/obese status. We aimed to investigate whether these associations are causal, using a two-sample Mendelian randomisation (MR) design. In addition, we compared results for LADA and type 2 diabetes.

Methods

We identified 43 SNPs acting through the fetal genome as instrumental variables (IVs) for own birthweight from a genome-wide association study (GWAS) of the Early Growth Genetics Consortium (EGG) and the UK Biobank. We identified 820 SNPs as IVs for adult BMI from a GWAS of the UK Biobank and the Genetic Investigation of ANthropometric Traits consortium (GIANT). Summary statistics for the associations between I

SUBMITTER: Wei Y 

PROVIDER: S-EPMC9345833 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature