Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling.

ABSTRACT: Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden. Physical exercise at times can be an effective remedy for frailty, but exercise therapy cannot be applied in all clinical cases. Medication is safer than exercise, but there are no drugs that reinforce both muscle and bone when administered alone. Multiple medications increase the risk of adverse events; thus, there is a need for individual drugs targeting both tissues. To this end, we established a novel sequential drug screening system and identified an aminoindazole derivative, locamidazole (LAMZ), which promotes both myogenesis and osteoblastogenesis while suppressing osteoclastogenesis. Administration of this drug enhanced locomotor function, with mus

SUBMITTER: Ono T 

PROVIDER: S-EPMC9345981 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature