Discriminators of pseudoprogression and true progression in high-grade gliomas: A systematic review and meta-analysis.

ABSTRACT: High-grade gliomas remain the most common primary brain tumour with limited treatments options and early recurrence rates following adjuvant treatments. However, differentiating true tumour progression (TTP) from treatment-related effects or pseudoprogression (PsP), may critically influence subsequent management options. Structural MRI is routinely employed to evaluate treatment responses, but misdiagnosis of TTP or PsP may lead to continuation of ineffective or premature cessation of effective treatments, respectively. A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses method. Embase, MEDLINE, Web of Science and Google Scholar were searched for methods applied to differentiate PsP and TTP, and stud

SUBMITTER: Taylor C 

PROVIDER: S-EPMC9345984 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature