Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution.

ABSTRACT: Small heat shock proteins (sHSPs) emerged early in evolution and occur in all domains of life and nearly in all species, including humans. Mutations in four sHSPs (HspB1, HspB3, HspB5, HspB8) are associated with neuromuscular disorders. The aim of this study is to investigate the evolutionary forces shaping these sHSPs during vertebrate evolution. We performed comparative evolutionary analyses on a set of orthologous sHSP sequences, based on the ratio of non-synonymous: synonymous substitution rates for each codon. We found that these sHSPs had been historically exposed to different degrees of purifying selection, decreasing in this order: HspB8 > HspB1, HspB5 > HspB3. Within each sHSP, regions with different degrees of purifying selection can be discerned, resulting in characteristic sele

SUBMITTER: Benndorf R 

PROVIDER: S-EPMC9346038 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature