The Role of Fc Gamma Receptors in Antibody-Mediated Rejection of Kidney Transplants.

ABSTRACT: For the past decades, complement activation and complement-mediated destruction of allograft cells were considered to play a central role in anti-HLA antibody-mediated rejection (AMR) of kidney transplants. However, also complement-independent mechanisms are relevant in the downstream immune activation induced by donor-specific antibodies, such as Fc-gamma receptor (FcγR)-mediated direct cellular activation. This article reviews the literature regarding FcγR involvement in AMR, and the potential contribution of FcγR gene polymorphisms to the risk for antibody mediated rejection of kidney transplants. There is large heterogeneity between the studies, both in the definition of the clinical phenotypes and in the technical aspects. The study populations were generally quite small, except for t

SUBMITTER: Delpire B 

PROVIDER: S-EPMC9346079 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature