The clinical utility of cfRNA for disease detection and surveillance: A proof of concept study in non-small cell lung cancer.

ABSTRACT:

Background

CT scans are used in routine clinical practice for the diagnosis and treatment surveillance of non-small cell lung cancer (NSCLC). However, more sensitive methods are desirable. Liquid biopsy analyses of RNA and DNA can offer more sensitive diagnostic approaches. Cell-free RNA (cfRNA) has been described in several malignancies, but its clinical utility has not previously been explored.

Methods

We evaluated the clinical utility of cfRNA for early detection and surveillance of tumor disease in a proof-of-concept study. Using real-time-droplet digital polymerase chain reaction we characterized a candidate transcript (MORF4L2) in plasma samples from 41 advanced stage, 38 early stage NSCLC and 39 healthy samples. We compared its diagnostic performance with tumor marker

SUBMITTER: Metzenmacher M 

PROVIDER: S-EPMC9346179 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature