Non-invasive assessment of tissue sodium content in patients with primary adrenal insufficiency.

ABSTRACT:

Objective

Replacement therapy in primary adrenal insufficiency (PAI) with corticosteroids modulates sodium homeostasis. Serum sodium is, however, prone to osmotic shifts induced by several additional factors besides corticosteroids and does not always reliably reflect treatment quality. Non-osmotic tissue storage can be visualized by sodium MRI (23Na-MRI) and might better reflect corticosteroid activity.

Design

Longitudinal study of 8 patients with newly diagnosed PAI and cross-sectional study in 22 patients with chronic PAI is reported here. Comparison was made with matched healthy controls.

Methods

Using a 23Na-MRI protocol on a 3T scanner, relative sodium signal intensities (rSSI) to signal intensities of the reference vial with 100 mmol/L of sodium were determined

SUBMITTER: Chifu I 

PROVIDER: S-EPMC9346263 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature