MALAT1 Polymorphisms and Lung Cancer Susceptibility in a Chinese Northeast Han Population.

ABSTRACT: Background: LncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was competitive endogenous RNA (ceRNA) involved in various molecular processes for metastasis development in lung cancer. Single nucleotide polymorphisms (SNPs) in MALAT1 gene might be predictive markers for lung cancer. In our study, we selected rs619586 and rs3200401 in MALAT1 gene to explore their effects on lung cancer susceptibility. Methods: The case-control study included 444 lung cancer cases and 460 healthy controls. Genotyping was performed by Taqman allelic discrimination method. Logistic regression, Student t-test, and Chi-square test (χ² ) were used to analyze the data. Results: The findings of the study showed that rs3200401 was significantly associ

SUBMITTER: Tong G 

PROVIDER: S-EPMC9346381 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature