Genetic variants of interferon lambda-related genes and chronic kidney disease susceptibility in the Korean population.

ABSTRACT:

Background

Chronic kidney disease (CKD) is a common condition leading to renal dysfunction and is closely related to increased cardiovascular and mortality risk. CKD is an important public health issue, and recent genetic studies have verified common CKD susceptibility variants. This research examines the interrelationship between candidate genes polymorphisms of interferon lambda (IFNL) induction, its signaling pathway, and CKD.

Methods

Seventy-five patients with advanced CKD and 312 healthy subjects (as controls) participated in this research. A replication set composed of 172 patients with advanced CKD and 365 controls was used for additional analysis. The genotype of single nucleotide polymorphisms (SNPs) was determined by the Axiom Genome-Wide Human Assay and SNaPshot a

SUBMITTER: Kwak JH 

PROVIDER: S-EPMC9346399 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature