Vanillin-crosslinked chitosan/ZnO nanocomposites as a drug delivery system for 5-fluorouracil: study on the release behavior via mesoporous ZrO₂-Co₃O₄ nanoparticles modified sensor and antitumor activity.

ABSTRACT: Herein, a series of vanillin-crosslinked chitosan (Vn-CS) nanocomposites (NCs) containing various contents of ZnO nanoparticles (NPs) was prepared and characterized via FTIR spectroscopy, XRD, TGA, SEM and TEM. Changing the weight% of ZnO NPs in the prepared NCs resulted in an improvement in their antibacterial activity against Gram-negative and Gram-positive bacteria strains compared with the unmodified CS, and the encapsulation efficiency of 5-fluorouracil (5-FU) was found to be in the range of 61.4-69.2%. Subsequently, the release of 5-FU was monitored utilizing the mesoporous ZrO₂-Co₃O₄ NPs modified carbon paste sensor via the square-wave adsorptive anodic stripping voltammetry (SW-AdASV) technique. Also, the release mechanism of 5-FU from

SUBMITTER: Salahuddin N 

PROVIDER: S-EPMC9346502 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature