Human Amniotic Fluid Mesenchymal Stem Cell-Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR-369-3p/YAF2/PDCD5/p53 Pathway.
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ABSTRACT:
SUBMITTER: Geng Z
PROVIDER: S-EPMC9346541 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Human Amniotic Fluid Mesenchymal Stem Cell-Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR-369-3p/YAF2/PDCD5/p53 Pathway.
Geng Zixiang Z Chen Haiyang H Zou Gang G Yuan Long L Liu Peng P Li Bingrong B Zhang Kaiyong K Jing Fangyuan F Nie Xiaoli X Liu Te T Zhang Bimeng B
Oxidative medicine and cellular longevity 20220726
Human amniotic fluid stem cell-derived exosome (HuAFSC-exosome) transplantation is considered a promising treatment for premature ovarian failure (POF). However, its mechanism remains unclear. In this study, exosomes were isolated and enriched from HuAFSC subsets of CD44+/CD105+, and the exosomes were transplanted into a POF model <i>in vitro</i> and <i>in vivo</i>. Our results confirmed that the exosomes produced by CD44+/CD105+ HuAFSCs could achieve therapeutic effects in a mouse POF model. Ou ...[more]
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