Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout.

ABSTRACT:

Importance

Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated.

Objective

To investigate whether there is a transient increase in risk of cardiovascular events after a recent gout flare.

Design, setting, and participants

A retrospective observational study was conducted using electronic health records from the Clinical Practice Research Datalink in England between January 1, 1997, and December 31, 2020. A multivariable nested case-control study was performed among 62 574 patients with gout, and a self-controlled case series, adjusted for season and age, was performed among 1421 patients with gout flare and cardiovascular event.

Exposures

Gout flares were ascertained us

SUBMITTER: Cipolletta E 

PROVIDER: S-EPMC9346550 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature