Incidence of Acute Chest Syndrome in Children With Sickle Cell Disease Following Implementation of the 13-Valent Pneumococcal Conjugate Vaccine in France.

ABSTRACT:

Importance

Acute chest syndrome (ACS) is one of the leading acute severe complications of sickle-cell disease (SCD). Although Streptococcus pneumoniae (S pneumoniae) is highly prevalent in children with SCD, its precise role in ACS is unclear. The efficacy of 13-valent pneumococcal conjugate vaccine (PCV13) implementation on ACS is still unknown.

Objective

To assess the association of PCV13 implementation in the general pediatric population with the incidence of ACS in children with SCD.

Design, setting, and participants

This cohort study used an interrupted time-series analysis of patient records from a national hospital-based French surveillance system. All children younger than 18 years with SCD (based on the International Statistical Classification of Diseases and

SUBMITTER: Assad Z 

PROVIDER: S-EPMC9346553 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature