Impact of an Adenosine A_2A Receptor Agonist and Antagonist on Binding of the Dopamine D₂ Receptor Ligand [¹¹C]raclopride in the Rodent Striatum.

ABSTRACT: Adenosine A_2A and dopamine D₂ receptors in the basal ganglia form heterotetrameric structures that are involved in the regulation of motor activity and neuropsychiatric functions. The present study examines the A_2A receptor-mediated modulation of D₂ receptor binding in vivo using positron emission tomography (PET) with the D₂ antagonist tracer [¹¹C]raclopride. Healthy male Wistar rats (n = 8) were scanned (60 min dynamic scan) with [¹¹C]raclopride at baseline and 7 days later following an acute administration of the A_2A agonist CGS21680 (1 mg/kg), using a MicroPET Focus-220 camera. Nondisplaceable binding potential (BP_ND) values were calculated using a simplified reference tissue model

SUBMITTER: Prasad K 

PROVIDER: S-EPMC9346611 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature