Expedient approach for trans-esterification of β-keto esters under solvent free conditions using silica supported boric acid (SiO₂-H₃BO₃) as a recyclable catalyst.

ABSTRACT: A highly efficient trans-esterification of β-keto methyl/ethyl esters with primary, secondary, allylic, benzylic and chiral alcohols has been carried out in excellent yields under solvent-free conditions using silica supported boric acid as a heterogeneous catalyst. The surface morphology of the silica-boric acid catalyst (fresh and recycled) has been characterized by SEM and EDX techniques. This sustainable protocol resulted in a remarkable enhancement in the synthetic efficiency (87-95% yield) with high purity and eliminating the use of an environmentally toxic solvent. The work up procedure is very simple and the catalyst has been successfully recovered and recycled. The present methodology is also applicable for trans-esterification with chiral alcohols on a multi-gram scale without co

SUBMITTER: Das K 

PROVIDER: S-EPMC9346990 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature