Once-Weekly Exenatide in Youth With Type 2 Diabetes.

ABSTRACT:

Objective

Approved treatments for type 2 diabetes in pediatric patients include metformin, liraglutide, and insulin. However, approximately one-half of the youth fail metformin monotherapy within 1 year, insulin therapy is associated with challenges, and liraglutide requires daily injections. Consequently, the efficacy and safety of once-weekly injections of exenatide for the treatment of youth with type 2 diabetes was evaluated.

Research design and methods

Participants (aged 10 to <18 years) were randomized (5:2) to once-weekly exenatide 2 mg or placebo, respectively. The primary efficacy end point was change in glycated hemoglobin from baseline to week 24. Secondary efficacy end points were also evaluated, and the frequency of adverse events (AEs) was assessed.

Results<

SUBMITTER: Tamborlane WV 

PROVIDER: S-EPMC9346995 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature