Combining PET with MRI to improve predictions of progression from mild cognitive impairment to Alzheimer's disease: an exploratory radiomic analysis study.

ABSTRACT:

Background

This study aimed to explore the potential of a combination of 18F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) and magnetic resonance imaging (MRI) to improve predictions of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The predictive performances and specific associated biomarkers of these imaging techniques used alone (single-modality imaging) and in combination (dual-modality imaging) were compared.

Methods

This study enrolled 377 patients with MCI and 94 healthy control participants from 2 medical centers. Enrolment was based on the patients' brain MRI and PET images. Radiomic analysis was performed to evaluate the predictive performance of dual-modality ¹⁸F-FDG PET and MRI scans. Regions of

SUBMITTER: Yang F 

PROVIDER: S-EPMC9347042 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature