The efficacy and safety of chimeric antigen receptor T cells in digestive system cancers: a systematic review and meta-analysis.

ABSTRACT:

Background

As a successful treatment for hematological malignancy, chimeric antigen receptor T cells (CAR-T cells) have been expanded to solid tumors to demonstrate their safety and efficacy, especially for digestive system cancer (DSC). Various CAR-T cell constructs used in different types of DSCs result in heterogeneous responses. Thus, we aimed to systematically summarize the clinical response of DSCs treated with CAR-T cells and investigate factors associated with heterogeneity in outcomes.

Methods

Clinical studies of DSC patients treated with CAR-T cell therapy were selected from the PubMed, Cochrane, Embase, Web of Science databases before October 1, 2020. "CAR-T cell", "solid tumor" and their synonymous terms were used to construct the search strategy. Duplicates, rev

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9347051 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature