Identification of immune-related biomarkers in embryos with neural tube defects via a bioinformatics analysis.

ABSTRACT:

Background

Neural tube defects (NTDs) are one of the most common types of birth defects. Oral folic acid (FA) prophylaxis is currently available, but the pathogenesis of NTDs is not fully understood. We conducted this study to examine the role of the immune landscape of NTDs and identify novel diagnostic and therapeutic biomarkers.

Methods

We downloaded the GSE33111 data set of 12 NTD embryos and 12 healthy embryos in the same period of fetal development from the Gene Expression Omnibus (GEO) database. We compared the healthy embryos and NTD embryos to identify the differentially expressed genes (DEGs). We also performed a functional enrichment analysis of the DEGs using the clusterProfiler package. We extracted the top 10 ranked genes as hub immune-related biomarkers. We th

SUBMITTER: Huang Q 

PROVIDER: S-EPMC9347061 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature