Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration.

ABSTRACT:

Background

Intervertebral disc (IVD) is a highly rhythmic tissue, which experiences a diurnal cycle of high/low mechanical loading via the changes of activity/rest phase. There are signs that disruption of the peripheral IVD clock is related to the process of intervertebral disc degeneration (IDD). However, it is still unclear whether inflammation could disturb the IVD clock and thus induce the process of IDD.

Methods and results

In this study, we used IL-1β, a commonly used inflammatory factor, to induce IDD and found that the IVD clock was dampened in degenerated human nucleus pulposus specimens, rat nucleus pulposus (NP) tissues, and cells. In this study, we found that the circadian clock of NP cells was totally disrupted by knockdown of the core clock gene brain and musc

SUBMITTER: Peng P 

PROVIDER: S-EPMC9347076 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature