A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation.

ABSTRACT:

Background

Glioblastoma (GB) is the most common and most aggressive malignant brain tumor. In understanding its resistance to conventional treatments, iron metabolism and related pathways may represent a novel avenue. As for many cancer cells, GB cell growth is dependent on iron, which is tightly involved in red-ox reactions related to radiotherapy effectiveness. From new observations indicating an impact of RX radiations on the expression of ceruloplasmin (CP), an important regulator of iron metabolism, the aim of the present work was to study the functional effects of constitutive expression of CP within GB lines in response to beam radiation depending on the oxygen status (21% O₂ versus 3% O₂).

Methods and results

After analysis of radiation response

SUBMITTER: Roy C 

PROVIDER: S-EPMC9347084 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature